Synthesis of acylhydrazino-peptomers, a new class of peptidomimetics, by consecutive Ugi and hydrazino-Ugi reactions

• Angélica de Fátima S. Barreto,
• Veronica Alves dos Santos and
• Carlos Kleber Z. Andrade

Beilstein J. Org. Chem. 2016, 12, 2865–2872, doi:10.3762/bjoc.12.285

• peptidomimetics with potential biological activity. Keywords: acylhydrazino-peptomers; consecutive Ugi reactions; peptide-peptoid hybrid; peptomer; Introduction In the last decades, increasing efforts have been extensively carried out to improve the pharmacological properties of natural peptides by structural

• structures have also been carried out to obtain the less common but also biologically active azapeptoids [40], hydrazino-azapeptoids [41][42], retro hydrazino-azapeptoids [43] and peptoid-azapeptoid hybrids [39]. Recently, Seo et al. [44] reported the synthesis of a library of peptide-peptoid hybrid (termed